GreenLight is dedicated to bringing our Cell-Free process for the production of RNA to market to address global needs and threats. The team at GreenLight is composed of world leaders in diverse fields all working towards one goal. A dynamic and fast-paced environment is cultivated with employees not only aligned with GreenLight's mission, but also passionate about the technology and science. We are always seeking passionate and talented people that are ready to lead the coming RNA revolution.

GreenLight is an equal opportunity employer. We pride ourselves on the diversity of our workforce. We believe in a culture of transparency, integrity, gender equality and inclusion.


Open Positions


Senior Engineer – Process development, Pilot Plant, Scale-up and Manufacturing

Position Summary:

GreenLight Biosciences is seeking an exceptional, highly-motivated scale-up and manufacturing engineer to scale up cell-free bioprocessing and manufacture products using our core technology. The successful candidate will integrate with process development team and manage people and resources to scale the bio-processes to pilot and commercial scale. Strong technical, organizational, management and communication skills, and ability to cope up with a fast-paced environment, are essential.

 

Responsibilities:

  • Review, evaluate, develop manufacturing processes with man, machine, material and methods considered.

  • Develop, evaluate, and review instructions, specifications and methods to support the product life cycle transitions from development into production.

  • Lead/Perform cell-culture and cell free production campaigns (pilot-commercial) scale to support process definition, product development, demonstration runs for multiple programs in the pipeline.

  • Prepares product and process reports by collecting, analyzing, and summarizing information and trends.

  • Provides manufacturing decision-making information to support capacity planning for labor, production schedules, and estimating future requirements.

  • Completes design and development projects by training and guiding manufacturing personnel.

  • Has a firm understanding of all equipment for which he/she is responsible to include set-up, adjustment and assessment of possible improvements.

 

Qualifications:

  • Ph.D. in chemical engineering, biological engineering, or equivalent.

  • 7+ years of work experience in industrial biotechnology, food or pharmaceutical industry in a pilot plant process development and/or manufacturing setting.

  • Must have hands on experience with bioreactors/fermenters and related unit operations (such as primary cell separation, filtration, HTST, and drying unit operations) in bench, pilot and commercial scale.

  • Must have proven experience in process planning and development (project management, capacity planning, floor layout, material flows, capabilities).

  • Proven record of equipment design & selection, development and validation.

  • Fundamental understanding of principles of biochemical engineering, material & energy balances, scale up and manufacturing is required.

  • Proven record of commercializing bioprocesses from early stage to production stage is desired.

  • Experience with technical transfer of materials and processes to customers and/or contract manufacturing facilities is a plus.

  • Must be able to read engineering drawings.

  • Must be familiar with continuous improvement philosophy and implementation: statistical tools, Lean principles, six sigma, etc.

  • Experience with ASPEN, or similar software is a plus.

  • History of progressive responsibility and people management is a plus.

  • Must be highly-motivated with exceptional communication, leadership, and teamwork skills.


Sr. Scientist, Regulatory Science

Position Summary

GreenLight Biosciences is seeking an exceptional, highly-motivated professional for a position as Sr Scientist, Regulatory Science. In this position, you will be responsible for coordinating the regulatory approval processes for our biotechnology products.

Working closely with a team of highly motivated colleagues, while establishing a broad network of external contacts, you will play a key role in building an exciting future for GreenLight Biosciences. It is an incredible opportunity to gain a broad experience in an innovative and fast-paced environment; a chance of work with highly motivated and professional team; a chance to build the future of RNA revolution. Come and join us in this journey.

Responsibilities

• Prepare, submit and manage high quality scientific dossiers in accordance with relevant legislation

• Draft, execute and manage regulatory submission and ensure regulatory compliance throughout launch and commercialization of products

• Ensure compliant labeling as well as respective documentation in internal and external databases

• Establish professional relationships with regulatory authorities and external CROs

• Facilitate regulatory approval strategy development

• Develop and implement internal processes, SOPs and document controls for regulatory registrations and compliance.

• Keep abreast of latest regulatory scientific and policy developments and related issues

• Advising the business of timeframes, costs and work involved in new registrations, labeled use expansion, geographic expansions, product registration defenses, etc.

Qualifications

• Minimum of Bachelor’s degree in Chemistry, Crop Science, Toxicology, Ecotoxicology, Agronomy, Biochemistry, Bioscience Engineering, Entomology, Microbiology, Molecular Biology, Genetics, Plant Breeding, Plant Pathology or related scientific disciplines

• 5+ years of industrial experience in a regulatory function in the Agriculture Sector

• Solid knowledge of relevant regulatory legislations and relevant product registration processes

• Prior experience working with government agencies and external CROs is a plus

• Prior experience of successfully driving projects from inception to completion to meet shifting needs and/or developing and executing strategic plans

• Strong written and oral communication and organizational skills, with a proven ability to convey complex ideas in a clear, precise, and actionable manner

• Ability to successfully interact with diverse people and teams and continually build partnerships

• Track record of leading projects through influence while building stakeholder alignment

• Initiative, foresight and eye for detail


Downstream Process Engineer/Scientist

Position summary:

GreenLight Biosciences is seeking an exceptional, highly-motivated Downstream Process Engineer/Scientist with expertise in industrial-scale purification of molecular biology enzymes, proteins and/or nucleic acids to work on the scale-up of cutting edge technology in Cell-free Bioprocessing. The successful candidate will define and develop scalable recovery processes at the benchtop scale by applying state-of-the-art DSP techniques in the context of milestone-driven projects and will scale those processes from benchtop- to pilot- to industrial-scale. Strong technical, organizational, and communication skills, as well as the ability to develop creative solutions to challenging problems, are essential.

Responsibilities:

  • Design, development and implementation of robust purification schemes for recovering enzymes, proteins and/or nucleic acids from microbial cells using scalable separation techniques (e.g., TFF/MF/UF/DF, chromatography, drying unit operations).

  • Collaborate with enzymologists, molecular engineers, analytical chemists and customers to achieve purity and composition requirements and specifications and to ensure processes are compatible with commercial scale operations. 

  • Work with technoeconomic models to evaluate and define cost effective downstream processes in silico, including design schemes, associated costs, and relevant technical assumptions.

  • Scale-up (and down) benchtop-scale purification processes to pilot-scale and industrial-scale.

  • Work with other team members to accomplish project goals and milestones.

  • Use creative problem-solving skills to independently troubleshoot experimental challenges.

  • Continuously contribute to the company’s intellectual property portfolio and routinely track and document results in laboratory notebooks and databases.

  • Analyze, summarize, and present experimental results to team members.

  • Stay current with competing technologies and the state of the art technologies and applications from the technical academic and patent literature, and vendors, in the relevant subject matter areas. 

  • Knowledgeable and considers safety and regulatory requirements with work.

Qualifications:

  • Advanced degree in chemical engineering, bioengineering, biochemistry, or equivalent.

  • 5+ years of industrial experience developing, scaling and commercialization of downstream processes for the purification of proteins and/or nucleic acids from microbial based systems 

  • Strong background in protein purification including precipitation is required.

  • Experience in nucleic acid purification is a plus.

  • Expertise with scalable separation techniques, such as MF/TFF/DF/UF and chromatography is required.

  • Expertise with scalable cell rupture methods is a plus. 

  • Must be highly-motivated with exceptional communication, leadership, and teamwork skills.


 

Scientist I/II – Nucleic Acid Biochemistry

Position Summary

GreenLight Biosciences is seeking an exceptional and highly motivated analytical scientist to help advance the company’s RNA platform technology. The successful candidate will support R&D efforts within the company by characterizing RNA products with respect to structure, sequence, and modifications. A deep technical background in analytical chemistry, molecular biology, and assay development is required. Strong organizational and communication skills, creative problem-solving, and flexibility are essential.

 Responsibilities:

  • Characterize the structure, sequence, and modifications of RNA molecules using state-of-the-art techniques, including HPLC, LC-MS/MS, capillary electrophoresis, next-generation sequencing, etc.

  • Purify RNA products using state-of-the art techniques, such as reverse-phase chromatography, ion exchange chromatography, size exclusion chromatography, solid-phase extraction, etc.

  • Evaluate purity of RNA samples for nucleic acid, protein, and other contaminants

  • Design and perform standard molecular biology experiments (DNA cloning, nuclease digestion, PCR, (q)RT-PCR, agarose gel electrophoresis, etc.)

  • Develop novel analytical methods where necessary

  • Work independently and in collaboration with multidisciplinary project teams, as well as the Analytical Chemistry and Metabolic Engineering groups

  • Maintain diligent and organized records

  • Clearly communicate results and recommendations to colleagues, managers, and senior management, assisting in project decision-making

 Qualifications:

  • Ph.D. in Biochemistry, Molecular Biology, or related discipline with at least 3 years of industrial experience or 5 years of academic experience, specializing in the RNA field. Candidates with a M.S. and at least 8 years of industrial experience in the RNA field will also be considered.

  • Experience characterizing nucleic acid modifications, including nucleoside and post-transcriptional modifications (e.g. 5’-cap structures, polyadenylation, etc.) is required

  • Experience characterizing primary and secondary structures of nucleic acids is required

  • Experience developing analytical chemistry methods (e.g. HPLC and LC-MS) is required

  • Experience with standard molecular biology techniques is required

  • Experience with next-generation approaches to RNA sequencing is desirable

  • Experience translating bench scale experiments to high throughput workflows is desirable

  • Strong organization, communication, and interpersonal skills are required, with the ability to work both independently and in a collaborative work environment


Scientist I/II – Strain Engineering

Position Summary

GreenLight Biosciences is seeking an exceptional and highly motivated microbial strain engineer to help advance the company’s RNA platform technology.  The successful candidate will support R&D efforts within the company by engineering microbial genomes and building DNA-based constructs to provide inputs to the company’s proprietary bioproduction technology.  A strong technical background in synthetic biology, microbial physiology and bioinformatics is required.  Strong organizational and communication skills, creative problem-solving, and flexibility are essential for thriving in this small start-up company with a fast-paced environment.

 Responsibilities:

  • Design, build, and optimize microbial strains employing standard molecular biology techniques such as PCR, DNA subcloning, agarose gel electrophoresis, DNA sequencing analysis, cell transformation, cell culture, and other more advanced methods in support of strain development projects

  • Execute & analyze small-scale experiments to test engineered strains prior to bench-scale fermentor trials

  • Collaborate with other Strain Engineering Team members to facilitate the successful achievement of project goals and milestones in a timely manner

  • Collaborate with the Fermentation Team for successful testing of new strains at bench-scale and beyond

  • Collaborate with the Pathway Engineering Team to deliver next-generation strains that advance GreenLight’s cell-free reaction technology

  • Work independently and as part of a team on multidisciplinary projects

  • Maintain diligent and organized records

  • Clearly communicate results and recommendations to colleagues, managers, and senior management, to assist in project decision-making

 Qualifications:

  • Ph.D. in Biochemistry, Chemical Engineering, Microbiology, or related discipline with at least 3 years of industrial experience or 5 years of academic experience, specializing in microbial strain engineering. Candidates with a M.S. and at least 8 years of industrial strain experience will also be considered.

  • Experience in working with Escherichia coli and Bacillus subtilis is required. Familiarity with other microorganisms would be a plus.

  • Deep understanding of chromosomal editing of microbial genomes is required, including use of CRISPR/Cas9 technology.

  • Handling of next-generation DNA sequencing data using appropriate bioinformatics tools is desirable

  • Experience translating bench-scale experiments to high throughput workflows is desirable

  • Strong organization, communication, and interpersonal skills are required, with the ability to multitask in a fast-paced environment.


Scientist / Engineer – mRNA Downstream Processing

 

Position Summary

GreenLight Biosciences is seeking an exceptional and highly motivated scientist or engineer to help advance the company’s RNA platform technology. The successful candidate will support R&D efforts within the company by developing scalable processes to purify messenger RNA (mRNA). A deep technical background in chromatography, centrifugation, filtration and end-to-end purification process development is required. Strong organizational and communication skills, creative problem-solving, and flexibility are essential.

Responsibilities:
 

  • Develop scalable processes for purification of clinical-grade messenger RNA, using a wide variety of chromatography, filtration, and centrifugation methods.

  • Manage downstream production of mRNA in-house, liaising with downstream counterparts at partners where appropriate.

  • Utilize current analytical methods and develop novel analytical methods where necessary to monitor product quality.

  • Work independently and in collaboration with multidisciplinary project teams, as well as the Analytical Chemistry and Metabolic Engineering groups.

  • Maintain diligent and organized records.

  • Clearly communicate results and recommendations to colleagues, managers, and senior management, assisting in project decision-making.

Qualifications:

  • Ph.D. in Chemical Engineering, Chemistry, Biochemistry, or related discipline with at least 3 years of industrial experience or 5 years of academic experience, specializing in the mRNA field. Candidates with a M.S. and at least 8 years of industrial experience in the mRNA field will also be considered.

  • Experience with nucleic acid process development (e.g. mRNA, dsRNA, DNA) is required.

  • Experience developing processes involving complex biological mixtures is required.

  • Experience developing chromatographic separation processes (including ion exchange, affinity, reverse-phase, size exclusion, etc.) and filtration processes (including ultrafiltration, tangential flow filtration, diafiltration, etc.) is required.

  • Experience scaling up / scaling down separation processes is required.

  • Experience with liquid chromatography (HPLC, FPLC) is required.

  • Experience with enzymatic reactions is desirable.

  • Knowledge of statistical design of experiments (DOE) is desirable.

  • Experience with Good Manufacturing Practices (GMP) is desirable.

  • Strong organization, communication, and interpersonal skills are required, with the ability to work both independently and in a collaborative work environment

Scientist I / II – Pathway & Process Development

 

Position Summary:

GreenLight Biosciences is seeking an exceptional, highly-motivated metabolic or biochemical engineer to work on cutting edge cell-free bioprocessing technology. The successful candidate will support research on the discovery, engineering, and optimization of biochemical pathways & processes in the context of several milestone-driven projects. Strong technical, organizational, and communication skills, as well as the ability to develop creative solutions to challenging problems, are essential.

 

Responsibilities:

  • Design, execute & analyze experiments at different scales (ranging from microliters to tens of liters) for pathway & process testing, debottlenecking & optimization

  • Research biological pathways and associated enzymes for the production of target molecules

  • Perform molecular biology techniques such as PCR, DNA subcloning, in vitro transcription, cell transformation, cell culture, and other more advanced methods in support of research projects

  • Collaborate with the analytical team to identify & develop analytical methods to investigate the cell-free reaction system

  • Collaborate with the downstream processing team in developing processes for improved recovery of pathway enzymes & products of interest

  • Work collaboratively with other team members to accomplish project goals and milestones

  • Use creative problem-solving skills to independently troubleshoot experimental challenges

  • Analyze, summarize, and present experimental results to team members and management

  • Contribute to technical discussions related to the development and application of GreenLight’s proprietary bioproduction technology

  • Continuously contribute to the company’s intellectual property portfolio and routinely track and document results in laboratory notebooks and databases

 

Qualifications:

  • Ph.D. in chemical engineering, bioengineering, molecular biology, biochemistry, or equivalent

  • 0-3 years of experience in the biotechnology industry

  • Fundamental understanding of principles of biochemical engineering, material & energy balances & metabolic networks is required

  • Strong background in molecular biology, microbial physiology, and biochemical pathway engineering with expertise on cutting-edge technologies for pathway/organism manipulation

  • Experience in process development, statistical design of experiments & modeling is highly desired

  • Familiarity with techniques for metabolite, protein & nucleic acid isolation, detection & quantitation as well as development of enzyme assays is a major plus

  • Must be highly-motivated with exceptional communication, leadership, and teamwork skills


Senior Research Associate, Product Development

Position Summary

Greenlight Biosciences has an exciting opportunity in the Product Development Team. We are looking for a talented formulation scientist that will utilize formulation expertise and scientific acumen to design and develop innovative agrochemical formulations and provide technical support to customers and stakeholders. The individual, if needed, will provide support in the technology transfer, regulatory process and process scale up. The individual should be skilled in the development of formulations for the agricultural, pharmaceutical, personal care or related products. It is an incredible opportunity to gain a broad experience in an innovative and fast-paced environment; a chance of work with highly motivated and professional team; a chance to build the future of RNA revolution. Come and join us in this journey.

 

Responsibilities

  • Design, develop and implement novel formulations and delivery systems based on dsRNA alone or in combination with other actives for foliar, seeds and soil applications through hands on experimentation

  • Perform stability studies and product testing procedures to demonstrate robust performance and shelf-life. Key testings include in house efficacy, microbial, physical-chemical testing, compatibility testing (container, tank mix, etc.). Proficient with ASTM and CIPAC methods

  • Active participation in the technical transfer of formulation processes to manufacturing facilities as well as collaborators

  • Support technical field development and sales team providing formulated samples and materials as needed

  • Interface with multidisciplinary teams, engage and collaborate with external partners to design and develop novel and effective solutions for dsRNA delivery

  • Ability to deliver complex ideas into clear results and proposals to influence individuals with diverse background

  • Present formulation updates to team member at regular project meetings as well as external audiences if necessary

  • Prepare and maintain laboratory notebooks, technical reports, summaries, protocols and methods according to company's policies and IP guidelines

  • Maintain a clean, organized and safe working environment

  • Stay current with the developments in formulation science and identify, evaluate and implement applications for novel delivery systems

 

Qualifications

  • B.S degree in Chemistry, Chemical Engineering, Colloidal Chemistry, or related field with up to 2 years of relevant industrial work experience or an M.S. with no additional years of experience.

  • Prior technical research experience in academia or industry

  • R&D work experience in formulation development of agricultural products desired but not required

  • Knowledge of various formulation types commonly used in the agriculture industry as well as field application practices is a plus

  • Proficient in experimental design and statistical methods

  • Energetic, self-motivated and self-directed, creative and capable of working effectively in a flexible, fast-paced and multi-disciplinary environment

  • Planning skills required to organize, prioritize, schedule and coordinate work activities for multiple projects

  • Ability to work in an environment with frequent changes in workload priorities, ability to prioritize tasks

  • Ability to work independently and drive projects to completion

  • Strong interpersonal and leadership skills required to communicate, advise, negotiate or influence others, as well build productive working relationships

  • Excellent verbal and written communication skills

 


Sr. Research Associate – Pathway Engineering

 

Position Summary:

GreenLight Biosciences is seeking an exceptional, highly-motivated Research Associate / Sr. Research Associate to work on cutting edge cell-free bioprocessing technology. The successful candidate will support research on the discovery, engineering, and optimization of biochemical pathways & processes in the context of several milestone-driven projects. Strong technical, organizational, and communication skills, as well as the ability to develop creative solutions to challenging problems, are essential.

Responsibilities:

  • Execute & analyze experiments and associated analytics (such as enzyme assays) at different scales (ranging from 10s of µLs to 10s of Ls) for pathway & process testing, debottlenecking & optimization

  • Independently plan & perform routine molecular biology techniques such as PCR, DNA subcloning, in vitro transcription, cell transformation, cell culture, protein expression & purification and other more advanced methods in support of research projects

  • Maintain detailed records about experimental protocols and procedures followed in the form of lab notebooks

  • Work collaboratively with other team members to accomplish project goals and milestones

  • Use creative problem-solving skills to independently troubleshoot experimental challenges

  • Analyze, summarize, and present experimental results to team members and management

  • Must demonstrate skills in multitasking, organization, attention to detail, interpersonal, communication, judgement, planning and prioritizing, recognizing cause and effect

  • Maintain a clean, organized and safe work environment

  • Contribute to technical discussions related to the development and application of GreenLight’s proprietary bioproduction technology

  • Continuously contribute to the company’s intellectual property portfolio and routinely track and document results in laboratory notebooks and databases

Qualifications:

  • B.S. or M.S. in chemical engineering, bioengineering, molecular biology, biochemistry, or equivalent

  • Two or more years of experience in the biotechnology or pharmaceutical industry

  • Strong background in molecular biology and biochemistry with experience in recombinant DNA technologies, protein analysis, cell transformation, and cell culture including:

    • Proficiency in microbial culturing and aseptic techniques (required)

    • Basic understanding of microbial metabolism and nutritional requirements (desired)

    • Experience engineering metabolic pathways in microbial hosts is (desired)

  • Familiarity with analytical techniques for metabolite, protein & nucleic acid detection & quantitation is a major plus

  • Must be highly-motivated with exceptional communication, leadership, and teamwork skills


Research Associate (I/II/III/Senior) and/or Postdoctoral Engineer – Process Development

GreenLight Biosciences is seeking exceptional, highly-motivated Research Associate(s) to work on the process development of cutting edge fermentations and cell free bioprocessing technology. The successful candidate will be involved in high throughput screening of strains/cell free reactions, and/or process development of commercially relevant fermentations/cell free reactions in 10 mL to 150 L reactors. The successful candidate will work hands-on in small teams to execute fermentation/cell free bioprocessing and other associated bioprocess unit operations with a high degree of excellence, in a fast-paced environment. A high degree of flexibility, creativity and initiative is essential for success. Strong technical, organization, communication, documentation, inter-personal, and trouble shooting skills are essential. The RA will comply with company policies and practices for EHS and will support company and organizational targets and functional growth plans. 

 

RESPONSIBILITIES:

 

  • Operate and monitor fermentations/cell free reactions and conduct associated analytics (such as optical densities, dry cell weights, culture plating, protein analysis), in small teams at different scales (10 mL to 150 L) with limited supervision.

  • Analyze experimental data and generate data driven conclusions for process development and optimization.

  • Summarize experimental results and present to team members, other engineers and scientists in the company.

  • Maintain detailed records about experimental protocols and procedures followed in the form of lab notebooks.

  • Keeps an inventory of chemicals, raw materials, and other components produced.

  • Weighs and checks raw materials. Makes media, assembles, and cleans equipment and processes.

  • Adheres to good manufacturing practices and standard operating procedures.

  • Assists in the revision and creation of process documents, such as SOPs.

  • Must demonstrate skills in organization, attention-to-detail, interpersonal communication, judgement, planning and prioritization, recognizing cause and effect.

  • Establish and follow written procedures for the clear and accurate documentation of equipment operation, process instructions and process data.

  • Maintain a clean, organized and safe work environment.

 

QUALIFICATIONS:

 

  • A.S. or B.S. or M.S or Ph.D. in Chemical Engineering, Biological Engineering, Molecular Biology, Biochemistry or equivalent.

  • 0-5 years of experience in biotechnology/food/pharma industry.

  • Relevant undergraduate/graduate experience in an academic or industrial setting will be preferred.

  • Proficiency with microbial culture and aseptic techniques is required.

  • Strong technical competence in microbial metabolism, microbiology, molecular biology is required.

  • Familiarity and practical understanding of how to correctly operate basic laboratory equipment: including fermenters, DO probes, pH meters, mass spec, lab scales, centrifuges, shakers, sterile hoods, etc.

  • Personal track record and accomplishments in laboratory and executing experiments. Attention to detail and ownership of work is critical.

  • Ability to read and follow detailed instructions and record information accurately.

  • Ability to observe and react with unexpected experimental results.

  • Data-driven decision maker with knowledge and experience in data management tools.

  • Demonstrated ability to prioritize multiple tasks and demand on resources and accomplish goals.

  • Ability to read and follow detailed instructions and record information accurately.

  • Ability to observe and react with unexpected experimental results.

  • Data-driven decision maker with knowledge and experience in data management tools.

  • Demonstrated ability to prioritize multiple tasks and demand on resources and accomplish goals.

  • High quality standards for one’s own work is required.

  • Strong Analytical, Problem Solving, Planning and Organizational skills.

  • Ability to work independently and in teams to meet objectives and timelines.

  • Ability to lift 40 lbs.

  • Ability to work evening shifts.

  • Experience in high through-put reactors is a plus.

  • Familiarity with analytical techniques for metabolite, protein, and nucleic acid detection and quantification is a plus.

  • Must be flexible, approachable, highly motivated, with excellent communication and interpersonal skills.

 

EDUCATION:

Associate’s, Bachelor’s, Master’s or Doctoral degree in Microbiology, Biochemistry, Chemical Engineering, Biological Engineering or similar Life Sciences discipline required.


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