GreenLight Biosciences Submits Regulatory Dossier in US, EU and Brazil for Groundbreaking RNA-Based Solution to Control Grape Powdery Mildew

BOSTON, Mass. – October 28, 2025 – GreenLight Biosciences ("the Company" or "GreenLight Bio"),a pioneering agricultural biotechnology company focused on nature-based solutions for plant health, today announced the submission of regulatory dossiers for its novel RNA-based fungicide to authorities in the United States, European Union, and Brazil. The product is designed to control Erysiphe necator (powdery mildew) in grapevines — a groundbreaking first in agricultural disease management.

These submissions mark a significant step in advancing sustainable, effective crop protection solutions globally. The product leverages RNA interference (RNAi) to precisely target powdery mildew, offering grape growers a powerful, environmentally friendly alternative to conventional fungicides.

“The submission of this dossier, thefirst-known RNA-based fungicide, demonstrates our ability to address the full spectrum of crop protection challenges, from insect to fungi to weeds,” said Andrey Zarur, CEO of GreenLight Biosciences. “This milestone underscores our commitment to harnessing the power of nature and highlights the strength of our platform to manufacture RNA-based solutions at any scale. This flexibility is key to meeting the diverse needs of growers worldwide and accelerating innovation in crop protection.”

GreenLight Bio’s RNA-based solution represents a new class of crop protection that specifically targets powdery mildew without impacting non-target species. Once registered, it will provide grape growers with a powerful tool to help manage resistance, maintain thelong-term efficacy of their pest management programs, and reduce reliance on chemical fungicides. The product is designed to be compatible with existing farm practices and equipment, requiring no special application machinery or storage. It can be applied throughout the crop cycle, offering flexible and effective disease management.

“Grape powdery mildew is a persistent and costly problem for growers, and this submission to several regulatory bodies across geographies marks a critical step toward offering a transformative solution,” said Mark Singleton, GM & Chief Commercial Officer. “Backed by multiple seasons of field trials around the world, we believe our RNA-based solution will offer an effective, highly targeted, and environmentally friendly alternative that can help protect harvests, reduce economic losses, and support the long-term health of vineyards.”

Grape powdery mildew, caused by the fungal pathogen Erysiphe necator, is one of the most widespread and economically damaging diseases in viticulture. It reduces yields, compromises fruit and wine quality, increases reliance on chemical fungicides, and drives concerns about pesticide residues and pathogen resistance. The disease can delay fruit maturity, reduce vine vigor, and weaken berry skins, making grapes more vulnerable to rot and secondary infections. For winemakers, even low-levelinfections can introduce off-flavors and negatively impact wine quality. In major grape-producing regions, annual management costs can reach hundreds of millions of dollars, with wine grape growers bearing a substantial portion of these costs.

GreenLight Biosciences also plans to submit registration dossiers for this solution in Argentina and Chile in the coming months, furthering its strategy to become a leading provider of crop protection solutions that support growers in the United States, European Union and Latin America.

About GreenLight Biosciences 

GreenLight Biosciences develops sustainable, effective, and user-friendly RNA-based solutions to help farmers and beekeepers enhance crop resilience and improve pollinator health.  With a growing pipeline of targeted insecticides, fungicides, and herbicides, GreenLight Bio is the only company with registered applied RNA products globally - including Calantha™, for Colorado potato beetle, and Norroa™, for varroa mites. GreenLight Bio’s end-to-end capability to design, develop, and register RNA-based solutions is driving innovation in sustainable agriculture. The company’s proprietary manufacturing platform enables scalable, cost-effective production of RNA for targeted, environmentally responsible crop protection tools.

 
Media Contact 
Kendra Guerrero

kendra.guerrero@fgsglobal.com

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